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Tumor-associated macrophage-mediated delivery of nano-photosensitizer enables light-induced metabolic programming for immuno-photodynamic therapy

摘要Dear Editor,Tumor-associated macrophages(TAMs)account for up to 50%of tumor mass and serve as key innate immune cells in the tumor microenvironment(Kzhyshkowska et al.,2024).TAMs are primarily M2-like phenotypes that contribute to tumor immunosuppression and promote immune escape by secreting anti-inflammatory fac-tors,thereby supporting tumor growth,metastasis,and angiogenesis.

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作者 Hong Deng [1] Huimin Wang [1] Yiyi Zhang [1] Runmeng Liu [1] Wei Hou [1] Lin Wang [2] Haiyan Xu [3] Weiqi Zhang [1] 学术成果认领
作者单位 State Key Laboratory of Complex Severe and Rare Diseases,Institute of Basic Medical Sciences,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100005,China;Department of Biomedical Engineering,Institute of Basic Medical Sciences,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100005,China [1] State Key Laboratory of Common Mechanism Research for Major Diseases,Institute of Basic Medical Sciences,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100005,China [2] Department of Biomedical Engineering,Institute of Basic Medical Sciences,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100005,China [3]
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DOI 10.1093/procel/pwaf064
发布时间 2026-01-24(万方平台首次上网日期,不代表论文的发表时间)
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蛋白质与细胞

蛋白质与细胞

2025年16卷12期

1060-1065页

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