换一批
换一批eIF-4E、p53在皮肤鳞状细胞癌中的表达及其临床意义
The expression and the clinical significance of eukaryotic translation initiation factors 4E and p53 in squamous cell carcinoma
摘要Objective:To study the expression of eukaryotic initiation factor-4E (eIF-4E) and p53 in squamous cell carcino-mas (SCC) and to explore their relationship and clinical significance. Methods:The expression of eIF-4E and p53 in 32 cases of SCC was detected by immunohistochemical SABC method. Results:The positive rate of eIF-4E and p53 expression was 93.8% and 56.3% in SCC, and the levels of eIF-4E and p53 were significantly higher in SCC than those in the normal skin tissue (P < 0.05). Conclusion:Both eIF-4E and p53 were useful markers in SCC, but the specialty and sensitivity of the eIF-4E protein was high in SCC.
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