摘要Abstract A 43-year-old female with a 3-month history of paroxysmal irritating cough presented progressive chest tightness and shortness of breath. Laboratory data showed elevated carcino-embryonic antigen (CEA). Further imaging studies revealed a soft tissue mass shadow was in right middle lobe lung with mediastinal and sub-carinal lymph nodes enlarged.Biopsy diagnosis: moderately and poorly differentiated adenocarcinoma of the lung. Clinical diagnosis: central non-small cell lung cancer (NSCLC) of right middle lobe (CIVT4N2M1), lung adenocarcinoma G2–3, malignant pleural effusion, pericardial effusion, hilar and mediastina lymph node metastases. After 4 cycles of endostar plus GC therapy, imaging studies revealed showed soft tissue mass in right middle lobe disappeared, and evaluation of short-term result was complete remission (CR).PFS has been seven months till now. Therefore, this report provided strong evidence that endostatin combined GC treatment for advanced NSCLC is safe and effective, which can prolong survival and improve quality of life.