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一个新的胃癌预后记分

Novel prognostic score for patients with gastric carcinoma

摘要Objective: The lack of a simple criterion for gastric carcinoma creates a persistent challenge for clinicians trying to provide patients with useful prognostic information. The aim of this study was to identify baseline prognostic factors, and use this information to establish a simple criterion to predict outcome in gastric carcinoma. Methods: Between 2005 and 2010,155 patients with gastric carcinoma, were enrolled. Clinicopathologic prognostic factors were evaluated by univariate and multivariate analysis. Results: Of the 155 patients, 48 (30.9%) died. Three independent poor prognostic factors were identified by multivariate analysis: gross type > or = 3 (hazard ratio [HR], 1.564; 95% CI, 1.067 to 2.294), peritoneal dissemination (HR, 3.750; 95% CI, 1.760 to 7.989) and lymphatic duct invasion (HR, 3.578; 95% CI, 1.422 to 9.004). One point was added for each category among three independent prognostic factors. Prognostic score (PS) was determined by an aggregate of these points for each category. There existed a significant difference between survival of patients with PS 0 or 1 and 2 (P <0.0001). Conclusion: Three poor prognostic factors were identified and a simple criteria was devised. Information from this analysis can be used to predict prognosis of gastric carcinoma with a strict stratification.

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DOI 10.1007/s10330-011-0877-5
发布时间 2011-12-27(万方平台首次上网日期,不代表论文的发表时间)
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中德临床肿瘤学杂志(英文版)

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