摘要Objective: This study was aimed to explore the expression of microRNA-32 (miR-32) in multiple myeloma (MM), and study its association with β2-microglobulin and staging of MM by Durie-Salmon classification.Methods: The expression level of miR-32 in bone marrow mono-nuclear cels of MM were examined by real-time polymerase chain reaction (real-time PCR), and the correlations between the expression level of miR-32 and related clinic pathologic features β2-microglobulin, staging of MM by Durie-Salmon classification were further analyzed.Results: The expression of miR-32 in MM patients was obviously higher than that in normal control (P < 0.05). The expression of miR-32 in relapsed/refractory MM patients was obvi-ously higher than that in newly diagnosed MM patients. The expression of miR-32 in MM patients decreased after chemical therapy than that before treatment, especialy in efective group (P < 0.05). There was no statisticaly significant change in inefective/progress group after chemical therapy (P > 0.05) .The expression of miR-32 was associated to staging of MM andβ2-microglobulin level.Conclusion: Expression level of miR-32 in MM patients is significantly higher than that in normal bone marrow, these data indicated that miR-32 may play an important role in the development of MM. High-regulated expression of miR-32 was associated with β2-microglobulin and staging of MM by Durie-Salmon classification.