摘要Objective: The purpose of this study was to evaluate the performance of the phase-binning algorithm and am-plitude-binning algorithm for four-dimensional computed tomography (4DCT) reconstruction in lung cancer radiation therapy. Methods: Quasar phantom data were used for evaluation.Aphantom of known geometry was mounted on a four-dimensional (4D) motion platform programmed with twelve respiratory waves (twelve lung patients trajectories) and scanned with a Philips Bril iance Big bore 16-slice CT simulator. The 4DCT images were reconstructed using both phase- and amplitude-binning algorithms. Internal target volumes (ITVs) of the phase- and amplitude-binned image sets were compared by evaluation of shape and volume distortions. Results: The phantom experiments il ustrated that, as expected, maximum inhalation occurred at the 0% amplitude and maximum exhalation occurred at the 50% amplitude of the amplitude-binned 4DCT image sets. The amplitude-binned algorithm rendered smal er ITV than the phase-binning algorithm. Conclusion: The amplitude-binning algorithm for 4DCT reconstruction may have a potential advantage in reducing the margin and protecting normal lung tissue from unnecessary irradiation.