摘要Objective The aim of the study was to systematically evaluate the correlation between IKZF1 polymorphisms and the risk of acute lymphoblastic leukemia. Methods Computer databases including PubMed, EMBASE, and Web of Science were searched for case-control studies on the association between IKZF1 polymorphisms and the risk of acute lymphoblastic leukemia. The retrieval period was from the establishment of the database to November 2020. Two researchers independently screened the literature, extracted the data, evaluated the risk of bias in the included studies, and used Stata 14.0 software for meta-analysis. Results A total of 48 case-control studies were included, with 10520 and 44049 cases in the case and control groups, respectively. The meta-analysis results showed that rs4132061 and rs11978267 of IKZF1 were significantly correlated with the risk of acute lymphoblastic leukemia (ALL). Conclusion Current evidence indicates that rs4132061 and rs11978267 of IKZF1 are significantly associated with the risk of B-cell ALL.