摘要We report the case of a 40-year-old female Chinese patient with gastric signet-ring cell carcinoma that wasfirst diagnosed because of paraneoplastic eosinophilia. The patient's eosinophil count reduced markedly to normal levels within 24 h after radical gastrectomy and Billroth Ⅱ anastomosis. The patient recovered well after the surgery and no abnormalities were found during the regular follow-ups. Paraneoplastic eosinophilia is an unusual manifestation that usually remains asymptomatic; moreover, cases of solid malignant tumors with eosinophilia are uncommon. To our knowledge, this is the first reported case of paraneoplastic eosinophilia in a patient with gastric carcinoma. We considered eosinophilia as a manifestation of a paraneoplastic syndrome, which can be the first clinical manifestation of a malignancy.