Research progress on immunotherapy targeting the tumor immune microenvironment for cholangiocarcinoma

二维码有效期 120s

摘要Cholangiocarcinoma (CCA) is the second most common hepatobiliary cancer, and its incidence has increased significantly in recent years. CCA has poor prognosis owing to the limited diagnosis and treatment options. The tumor immune microenvironment (TIME), which comprises immune cells, cytokines, and chemokines, plays a significant role in cancer progression, the evasion of immune surveillance, and therapeutic responses. Immunotherapeutic strategies targeting the TIME offer the potential for the recognition and eradication of CCA. This review discusses the cellular and molecular components of the TIME in CCA and immunotherapeutic strategies targeting it.

作者 Tianyin Ma ^[1] Zhang Chen ^[1] Yibo Chai ^[1] Xiangdong Gongye ^[1] Peng Xia ^[1] Chenming Qu ^[1] Ming Tian ^[1] Yufeng Yuan ^[2] 学术成果认领

作者单位 Department of Hepatobiliary and Pancreatic Surgery,Zhongnan Hospital of Wuhan University,Wuhan 430071,China;Clinical Medicine Research Center for Minimally Invasive Procedure of Hepatobiliary&Pancreatic Diseases of Hubei Province,Wuhan 430071,China ^[1] Department of Hepatobiliary and Pancreatic Surgery,Zhongnan Hospital of Wuhan University,Wuhan 430071,China;Clinical Medicine Research Center for Minimally Invasive Procedure of Hepatobiliary&Pancreatic Diseases of Hubei Province,Wuhan 430071,China;TaiKang Center for Life and Medical Sciences,Wuhan University,Wuhan 430071,China ^[2]

关键词 Cholangiocarcinoma Tumor Immune Microenvironment Tumor-Associated Macrophages Tumor-Infiltrating Lymphocytes Adoptive T-cell Transfer Immune Checkpoint Inhibitors Immunotherapy

DOI 10.1007/s10330-023-0642-2

发布时间 2023-05-22

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