Perspectives on the potential application of microRNAs in the diagnosis and treatment of triple-negative breast cancer

二维码有效期 120s

摘要Triple-negative breast cancer(TNBC)is currently the most heterogeneous and aggressive breast cancer type.It has a high recurrence rate,poor clinical prospects,and lack of predictive markers and potential treatment options.Dysregulated microRNAs(miRNAs)are involved in various cellular processes in TNBC.Moreover,variations in the miRNA levels in TNBC may act as a dependable indicator for predicting the effectiveness and specificity of treatments.Currently,the application of miRNAs for breast cancer therapy is primarily in the preclinical stage,with a focus on identifying highly specific and sensitive miRNAs that could offer new possibilities for early diagnosis,clinical treat-ment,and prognostic monitoring of TNBC.

作者 Yeqin Wu ^[1] Haitao Song ^[2] Huifang Shi ^[3] Gangping Wang ^[4] 学术成果认领

作者单位 Department of Pathology,the Fourth Affiliated Hospital of Zhejiang University School of Medicine,International School of Medicine Zhejiang University,In-ternational Institutes of Medicine Zhejiang University,Yiwu,China ^[1] Department of Oncology,the Rizhao People's Hospital,Rizhao,China ^[2] Central Laboratory,the Rizhao People's Hospital,Rizhao,China ^[3] Department of Pathology,the Fourth Affiliated Hospital of Zhejiang University School of Medicine,International School of Medicine Zhejiang University,In-ternational Institutes of Medicine Zhejiang University,Yiwu,China;Central Laboratory,the Rizhao People's Hospital,Rizhao,China ^[4]

关键词 Triple-negative breast cancer miRNA oncomiRs Tumorigenesis Prognosis Chemotherapy resistance

栏目名称

Perspectives

DOI 10.1097/ot9.0000000000000069

发布时间 2025-03-19

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