换一批
换一批Preparation and Photodynamic Anti-tumor Activity of Magnetic Polylactic Acid Nanoparticles Loaded with Photosensitizer
摘要A novel magnetic nanocarrier was strategically designed and successfully prepared. Photosensitizer 2, 7,12, 18-tetramethyl-3, 8-di-(1-propoxyethyl)-13, 17-bis-( 3-hydroxypropyl ) porphyrin ( PHPP ) wasencapsulated into polylactic acid (PLA)-coated Fe3O4nanoparticles. The diameter of nanocarrier is 30-50 nm by transmission electron micrograph ( TEM ). The encapsulation efficiency of photosensitizer is 27.98% calculated from UV-vis absorption spectra. The nanocarrier shows obvious photocytotoxic activity to Hela299 tumor cells in vitro.
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分类号
R318.51
发布时间
2010-12-17
基金项目
National Natural Science Foundations of China
Shanghai Municipal Natural Science Foundation, China
the Fundamental Research Funds for the Central Universities, China
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