换一批
换一批摘要Bisulfite sequencing (BS-seq) technology measures DNA methylation at single nucleotide resolution.A key task in BS-seq data analysis is to identify differentially methylation (DM) under different conditions.Here we provide a tutorial for BS-seq DM analysis using Bioconductor package DSS.DSS uses a beta-binomial model to characterize the sequence counts from BS-seq,and implements rigorous statistical method for hypothesis testing.It provides flexible functionalities for a variety of DM analyses.
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栏目名称
PROTOCOL AND TUTORIAL
发布时间
2020-04-29
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