摘要Background:The advancement of genomics has progressed in lightning speed over the past two decades.Numerous large-scale genome sequencing initiatives were announced,along with the rise of the holistic precision medicine approach.However,the field of genomic medicine has now come to a bottleneck since genomic-phenomic interactions are not fully comprehended due to the complexity of the human systems biology and environmental influence,hence the emergence of human phenomics.Results:This review attempts to provide an overview of the potential advantages of investigating the human phenomics of indigenous populations and the challenges ahead.Conclusion:We believe that the indigenous populations serve as an ideal model to excavate our understanding of genomic-environmental-phenomics interactions.