The indigenous populations as the model by nature to understand human genomic-phenomics interactions
摘要The advancement of genomic technology has progressed in a lightning speed. However, the understanding of genotype-phenotype interactions has come to a bottleneck owing to the complex interplays between the human biology and environment, hence posing hindrance to materialising precision medicine in a holistic manner. The newly emerging discipline on human phenomics may be the solution. We argue that the indigenous populations serve as an ideal model to excavate our understanding on genomic-environmental-phenomics interactions. This review provides an overview on the potential advantages of investigating the human phenomics in the indigenous populations, and the challenges ahead.
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