换一批摘要Sometimes ribosomes can misinterpret the stop codon and continue the translation to produce an extended protein. These events can occur by chance, as well as, by a programmed mechanism. However, the basis of this mechanism is still not known. In this paper, we report that the codon usage bias, at the end of the transcripts with UAA stop-codon, are a key determinant of the stop codon read-through. The non-optimal codon usage suggests that the canonical interpretation of the UAA codons might require ribosomal pause at the end of the coding region of the transcript.
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关键词
translational readthroughstop codonstranslational terminationribosomal density profilesnucleotide usage frequencytranslational readthroughstop codonstranslational terminationribosomal density profilesnucleotide usage frequency
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DOI
10.15302/J-QB-022-0298
发布时间
2024-07-26（万方平台首次上网日期，不代表论文的发表时间）
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