首页 > Quantitative Biology > Structural and dynamic properties of the YTH domain in complex with N6-methyladenosine RNA studied by accelerated molecular dynamics simulations

Structural and dynamic properties of the YTH domain in complex with N6-methyladenosine RNA studied by accelerated molecular dynamics simulations

导出 OA 学术成果认领

翻译打印收藏纠错

摘要N6-methyl adenosine (m6A) modifications play an important role in the regulation of RNA decay and gene expression at the post-transcriptional level. The YT521-B homology (YTH) domain-containing proteins can recognize m6A in numerous cellular processes. However, the binding mode of the YTH domain to m6A RNA is still unknown. In this work, we present an atomic description of the YTH-m6A RNA complex using computer simulations. The results have revealed the molecular mechanism of the RNA binding to the YTH domain. Our findings may be helpful for understanding the structural and dynamic characteristics of the YTH-m6A RNA complex.

作者 Mingwei Li ^[1] Guanglin Chen ^[2] Zhiyong Zhang ^[3] 学术成果认领

作者单位 MOE Key Laboratory for Membraneless Organelles & Cellular Dynamics, National Science Center for Physical Sciences at Microscale, Division of Life Sciences and Medicine, and Biomedical Sciences and Health Laboratory of Anhui Province, University of Science and Technology of China, Hefei 230026, China ^[1] Department of Physics, University of Science and Technology of China, Hefei 230026, China ^[2] MOE Key Laboratory for Membraneless Organelles & Cellular Dynamics, National Science Center for Physical Sciences at Microscale, Division of Life Sciences and Medicine, and Biomedical Sciences and Health Laboratory of Anhui Province, University of Science and Technology of China, Hefei 230026, China;Department of Physics, University of Science and Technology of China, Hefei 230026, China ^[3]

关键词 RNA methylation YTH-m6A3 RNA principal component analysis (PCA)binding free energy contact-based PCA RNA methylation YTH-m6A3 RNA principal component analysis (PCA)binding free energy contact-based PCA

栏目名称

RESEARCH ARTICLE

DOI 10.15302/J-QB-022-0297

发布时间 2024-07-26（万方平台首次上网日期，不代表论文的发表时间）

翻译满意度评价：

准确一般字义偏差语意偏离译文作用小提交