摘要Background : Elevated intracranial pressure (ICP) occurs in several physiological and pathological conditions, yet long- term sequellae are not common, which implies that blood flow is preserved above ischemic thresholds.Methods : This pilot study sought to confirm this hypothesis using a closed cranial window model in a rat in which ICP was elevated to 120 mmHg for 12 min, and superficial cortical perfusion was measured by laser Doppler flowmetry and laser speckle flowmetry. Results : Following a transient increase, cortical blood flow decreased to between 25％ and 75％ of baseline. These levels correspond to disrupted metabolism and de-creased protein synthesis but did not exceed thresholds for electrical signaling or membrane integrity. This may partially explain how some episodes of elevated ICP remain benign. Conclusion : The closed cranial window model provides a platform for prospective study of physiologic responses to artificially elevated ICP during neurosurgery to promote hemostasis.