摘要A lupus-like condition induced by intraperitoneal administration of pristane(2,6,10,14-tetramethylpentadecane)in mice is widely used as a model of systemic lupus erythe-matosus(SLE).Due to their phylogenetic distance from humans,murine models are not always suitable tool for studying the specific activity of therapeutic agents and the pathogenesis of SLE.In order to overcome species-specific limitations of murine mod-els,this approach was tested in non-human primates-cynomolgus monkeys(Macaca fascicularis).Two intraperitoneal injections at a dose of 3.5mL/kg,administered at weeks 1 and 23,recapitulated SLE features,including:production of antinuclear au-toantibodies(ANA),membranoproliferative glomerulonephritis with immune complex(IC)deposition in the glomeruli.However,from week 27 five of eight pristane-treated monkeys developed progressive respiratory failure.Two of these died at week28 and the remaining were euthanized at week32.The histology of the monkey lungs sug-gested exogenous lipoid pneumonia.Thus,while pristane induced serological autoim-munity and characteristic renal manifestations in Macaca fascicularis,the consequent lipoid pneumonia limited the observation period and prevented comprehensive evalu-ation of SLE manifestations beyond 32weeks.