摘要Biomedical research and preclinical testing in large animal models are essential for developing and evaluating new medical devices.This ovine study presents a step-wise implantation protocol and initial experiences with a wireless blood pressure implant sensor,enabling continuous telemetric monitoring in sheep.Adult female Jezersko-Sol?ava sheep underwent implantation of a wireless blood pressure sen-sor into the ascending aorta via the right carotid artery.The body of the device can was positioned subcutaneously in the lower neck region.After skin closure,a com-puted tomography scan was performed to verify sensor tip location.If malposition was detected,surgical revision was undertaken immediately.Wireless blood pres-sure monitoring was conducted over a 24h period in a custom-designed sheep barn.Twelve adult female sheep successfully underwent the implantation procedure,with no major complications reported.Sensor catheter revision was required in three ani-mals(25％).The mean duration of the procedure(from incision to skin closure)was 36±10 min.During the 24 h monitoring period,the average systolic and diastolic blood pressures were 93±6 and 65±5 mmHg,respectively.Large animal models,particularly sheep,are indispensable in cardiovascular device research due to their anatomical and physiological similarities to humans.This study demonstrates a rapid,minimally invasive protocol for wireless blood pressure sensor implantation in sheep,offering a valuable platform for chronic telemetric monitoring in the development of cardiovascular medical devices.