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Study of tree shrew biology and models:A booming and prosperous field for biomedical research

摘要The tree shrew(Tupaia belangeri)has long been proposed as a suitable alternative to non-human primates(NHPs)in biomedical and laboratory research due to its close evolutionary relationship with primates.In recent years,significant advances have facilitated tree shrew studies,including the determination of the tree shrew genome,genetic manipulation using spermatogonial stem cells,viral vector-mediated gene delivery,and mapping of the tree shrew brain atlas.However,the limited availability of tree shrews globally remains a substantial challenge in the field.Additionally,determining the key questions best answered using tree shrews constitutes another difficulty.Tree shrew models have historically been used to study hepatitis B virus(HBV)and hepatitis C virus(HCV)infection,myopia,and psychosocial stress-induced depression,with more recent studies focusing on developing animal models for infectious and neurodegenerative diseases.Despite these efforts,the impact of tree shrew models has not yet matched that of rodent or NHP models in biomedical research.This review summarizes the prominent advancements in tree shrew research and reflects on the key biological questions addressed using this model.We emphasize that intensive dedication and robust international collaboration are essential for achieving breakthroughs in tree shrew studies.The use of tree shrews as a unique resource is expected to gain considerable attention with the application of advanced techniques and the development of viable animal models,meeting the increasing demands of life science and biomedical research.

作者 Yong-Gang Yao ^[1] Li Lu ^[1] Rong-Jun Ni ^[2] Rui Bi ^[1] Ceshi Chen ^[3] Jia-Qi Chen ^[4] Eberhard Fuchs ^[5] Marina Gorbatyuk ^[6] Hao Lei ^[7] Hongli Li ^[8] Chunyu Liu ^[9] Long-Bao Lv ^[4] Kyoko Tsukiyama-Kohara ^[10] Michinori Kohara ^[11] Claudia Perez-Cruz ^[12] Gregor Rainer ^[13] Bao-Ci Shan ^[14] Fang Shen ^[15] An-Zhou Tang ^[16] Jing Wang ^[17] Wei Xia ^[16] Xueshan Xia ^[18] Ling Xu ^[1] Dandan Yu ^[1] Feng Zhang ^[9] Ping Zheng ^[1] Yong-Tang Zheng ^[1] Jumin Zhou ^[3] Jiang-Ning Zhou ^[19] 学术成果认领

作者单位 Key Laboratory of Genetic Evolution and Animal Models,Yunnan Key Laboratory of Animal Models and Human Disease Mechanisms,Kunming Institute of Zoology,Chinese Academy of Sciences,Kunming,Yunnan 650204,China;National Research Facility for Phenotypic&Genetic Analysis of Model Animals(Primate Facility),and National Resource Center for Non-Human Primates,Kunming Institute of Zoology,Chinese Academy of Sciences,Kunming,Yunnan 650107,China;KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases,Kunming Institute of Zoology,Chinese Academy of Sciences,Kunming,Yunnan 650204,China;Kunming College of Life Science,University of Chinese Academy of Sciences,Kunming,Yunnan 650204,China ^[1] Mental Health Center and Psychiatric Laboratory,West China Hospital,Sichuan University,Chengdu,Sichuan 610041,China;Sichuan Clinical Medical Research Center for Mental Disorders,Chengdu,Sichuan 610044,China ^[2] Key Laboratory of Genetic Evolution and Animal Models,Yunnan Key Laboratory of Animal Models and Human Disease Mechanisms,Kunming Institute of Zoology,Chinese Academy of Sciences,Kunming,Yunnan 650204,China ^[3] National Research Facility for Phenotypic&Genetic Analysis of Model Animals(Primate Facility),and National Resource Center for Non-Human Primates,Kunming Institute of Zoology,Chinese Academy of Sciences,Kunming,Yunnan 650107,China ^[4] German Primate Center,Leibniz Institute of Primate Research,G?ttingen 37077,Germany ^[5] Department of Optometry and Vision Science,School of Optometry,University of Alabama at Birmingham,Birmingham,AL 35294,USA ^[6] State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics,Innovation Academy for Precision Measurement Science and Technology,Chinese Academy of Sciences,Wuhan,Hubei 430071,China;Wuhan National Laboratory for Optoelectronics,Huazhong University of Science and Technology,Wuhan,Hubei 430074,China ^[7] Key Laboratory of Genetic Evolution and Animal Models,Yunnan Key Laboratory of Animal Models and Human Disease Mechanisms,Kunming Institute of Zoology,Chinese Academy of Sciences,Kunming,Yunnan 650204,China;National Research Facility for Phenotypic&Genetic Analysis of Model Animals(Primate Facility),and National Resource Center for Non-Human Primates,Kunming Institute of Zoology,Chinese Academy of Sciences,Kunming,Yunnan 650107,China;KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases,Kunming Institute of Zoology,Chinese Academy of Sciences,Kunming,Yunnan 650204,China ^[8] Soong Ching Ling Institute of Maternity and Child Health,International Peace Maternity and Child Health Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200030,China ^[9] Transboundary Animal Diseases Center,Joint Faculty of Veterinary Medicine,Kagoshima University,Kagoshima-city,Kagoshima 890-8580,Japan ^[10] Department of Microbiology and Cell Biology,Tokyo Metropolitan Institute of Medical Science,Tokyo 156-8506,Japan ^[11] Pharmacology Department,Cinvestav,Mexico City 07360,Mexico ^[12] Department of Medicine,University of Fribourg,Fribourg CH-1700,Switzerland ^[13] Beijing Engineering Research Center of Radiographic Techniques and Equipment,Institute of High Energy Physics,Chinese Academy of Sciences,Beijing 100049,China;School of Nuclear Science and Technology,University of Chinese Academy of Sciences,Beijing 100049,China ^[14] CAS Key Laboratory of Mental Health,Institute of Psychology,Chinese Academy of Sciences,Beijing 100101,China;Department of Psychology,University of Chinese Academy of Sciences,Beijing 100101,China ^[15] Department of Otorhinolaryngology Head and Neck Surgery,First Affiliated Hospital of Guangxi Medical University,Nanning,Guangxi 530000,China;Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor(Guangxi Medical University),Ministry of Education,Nanning,Guangxi 530000,China ^[16] Department of Neurobiology,School of Basic Medical Sciences,Nanjing Medical University,Nanjing,Jiangsu 211166,China ^[17] School of Public Health,Kunming Medical University,Kunming,Yunnan 650500,China ^[18] CAS Key Laboratory of Brain Function and Diseases,Division of Life Sciences and Medicine,University of Science and Technology of China,Hefei,Anhui 230027,China;Institute of Brain Science,First Affiliated Hospital of Anhui Medical University,Hefei,Anhui 230022,China ^[19]

关键词 Tree shrew Animal model Neurodegenerative diseases Infectious diseases Neuroscience Phenome

DOI 10.24272/j.issn.2095-8137.2024.199

发布时间 2024-11-27（万方平台首次上网日期，不代表论文的发表时间）

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