摘要The objective of this review is to identify the shortfalls of wheat-based,crude protein(CP)-reduced diets for broiler chickens as wheat is inferior to maize in this context but to inconsistent extents.Inherent factors in wheat may be compromising gut integrity;these include soluble non-starch polysaccharides(NSP),amylase trypsin inhibitors(ATI)and gluten.Soluble NSP in wheat induce increased gut viscosities,which can lead to compromised gut integrity,which is not entirely ameliorated by NSP-degrading feed enzymes.Wheat ATI probably compromise gut integrity and may also have the capacity to increase endogenous amino acid flows and decrease apparent starch and protein digestibilities.Gluten inclusions of 20 g/kg in a maize-soy diet depressed weight gain and feed intake and higher gluten inclusions have been shown to activate inflammatory cytokine-related genes in broiler chickens.Further research is required,perhaps particularly in relation to wheat ATI.The protein content of wheat is typically higher than maize;importantly,this results in higher inclusions of non-bound amino acids in CP-reduced broiler diets.These higher inclusions could trigger post-enteral amino acid imbalances,leading to the deamination of surplus amino acids and the generation of ammonia(NH3)which,if not adequately detoxified,results in compromised growth performance from NH3 overload.Thus,alternatives to non-bound amino acids to meet amino acid requirements in birds offered CP-reduced,wheat-based diets merit evaluation.The digestion of wheat starch is more rapid than that of maize starch which may be a disadvantage as the provision of some slowly digestible starch in broiler diets may enhance performance.Alternatively,slowly digestible starch may result in more de novo lipogenesis.Therefore,it may prove instructive to evaluate CP-reduced diets based on maize-wheat and/or sorghum-wheat blends rather than entirely wheat.This would reduce non-bound amino acid inclusions by lowering dietary CP derived from feed grains and may enhance starch digestive dynamics by retarding starch digestion rates.Also,the use of biomarkers to monitor gut integrity in broiler chickens is examined where calprotectin,ovo-transferrin and possibly citrulline appear to hold promise,but their validation requires further research.