摘要Tryptophan(Trp)is an essential amino acid that cannot be synthesized by animals.It has been char-acterized into two different isomers,levorotation-Trp(L-Trp)and dextrorotation-Trp(D-Trp),based on their distinct molecule orientation.Intestinal epithelial cells and gut microbiota are involved in metabolizing L-Trp in the gut via the activation of the kynurenine,serotonin,and indole pathways.However,knowledge regarding D-Trp metabolism in the gut remains unclear.In this review,we briefly update the current understanding of intestinal L/D-Trp metabolism and the function of their metabolites in modulating the gut physiology and diseases.Finally,we summarize the effects of Trp nutrition on swine production at different stages,including growth performance in weaned piglets and growing pigs,as well as the reproduction performance in sows.
作者单位Laboratory of Animal Nutritional Physiology and Metabolic Process,Institute of Subtropical Agriculture,Chinese Academy of Science,Changsha,Hunan 410125,China[1]Animal Nutritional Genome and Germplasm Innovation Research Center,College of Animal Science and Technology,Hunan Agricultural University,Changsha,Hunan 410128,China[2]Tianjin Institute of Industrial Biotechnology,Chinese Academy of Sciences,National Center of Technology Innovation for Synthetic Biology,Tianjin 300308,China;Animal Nutritional Genome and Germplasm Innovation Research Center,College of Animal Science and Technology,Hunan Agricultural University,Changsha,Hunan 410128,China;Laboratory of Animal Nutritional Physiology and Metabolic Process,Institute of Subtropical Agriculture,Chinese Academy of Science,Changsha,Hunan 410125,China[3]
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