摘要The global trend towards raising broiler chickens without the use of in-feed antibiotics(IFAs)means that there is an ongoing need to develop alternative treatments capable of delivering the benefits that IFAs previously provided.IFAs supported the productivity performance of chickens and played a key role in maintaining their health.Necrotic enteritis(NE)is an important disease of broilers that affects health,productivity,and welfare,and was previously well controlled by IFAs.However,with the reduction in IFA use,NE is resurgent in some countries.Vaccines and various feed additives,including pre-,pro-,and postbiotics,phytobiotics,fatty acids,and phage therapies have been introduced as alternative methods of NE control.While some of these feed additives have specific activity against the NE pathogen,Clostridium perfringens,most have the more general goal of reinforcing gut health.Extensive reviews of the effects of many of these feed additives on gut health have been published recently.Hence,rather than cover previously well reviewed areas of research this review focuses on the challenges and pitfalls in under-taking experimental assessment of alternative NE treatments and translating laboratory research to real world commercial production settings.The review is based on the author's particular experience,reading,thoughts,and analysis of the available information and inevitably presents a particular un-derstanding that is likely to be at odds with others thinking on these issues.It is put forward to stimulate thinking and discussion on the issues covered.