Mechanisms ofvascularization inmurine models ofprimary andmetastatic tumor growth

二维码有效期 120s

摘要Directed capillary ingrowth has long been considered synonymous with tumor vascularization. However, the vascu?lature of primary tumors and metastases is not necessarily formed by endothelial cell sprouting; instead, malignant tumors can acquire blood vessels via alternative vascularization mechanisms, such as intussusceptive microvascular growth, vessel co?option, and glomeruloid angiogenesis. Importantly, in response to anti?angiogenic therapies, malig?nant tumors can switch from one vascularization mechanism to another. In this article, we brielfy review the biological features of these mechanisms and discuss on their signiifcance in medical oncology.

作者单位 1st Department of Pathology and Experimental Cancer Research, Semmelweis University, üll?i út 26, Budapest 1085, Hungary ^[1] Department of Thoracic Surgery, Semmelweis University-National Institute of Oncology, Budapest 1122, Hungary ^[2]

关键词 Vascularization Primary tumor Metastasis Angiogenesis

DOI 10.1186/s40880-016-0083-5

发布时间 2016-04-07

翻译满意度评价：

准确一般字义偏差语意偏离译文作用小提交