来自一项艾日布林联合吉西他滨对比紫杉醇联合吉西他滨作为HER2阴性转移性乳腺癌的一线化疗的II期、多中心、随机试验的包含神经病变相关量表的生活质量结果:韩国癌症研究组试验(KCSG BR13-11)

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摘要背景与目的一项比较艾日布林联合吉西他滨(eribulin plus gemcitabine,EG)或紫杉醇联合吉西他滨(paclitaxel plus gemcitabine,PG)作为转移性乳腺癌(metastatic breast cancer,MBC)患者一线化疗方案的II期临床试验发现,EG方案的神经毒性较低,但疗效与PG方案相似.在本研究中,我们分析了该临床实验中的癌症患者生命质量测评量表-紫杉烷(functional assessment of cancer therapy-taxane,FACT-Taxane)问卷评分以确定他们的生活质量(quality of life,QoL).方法使用韩国版的FACT-Taxane问卷评估QoL.在评估基线之后,前12个疗程中每2个疗程评估1次QoL,之后每3个疗程评估1次QoL.使用线性混合模型评估EG组和PG组QoL的差异.结果在118例入组患者中,117例在基线时回复了FACT-Taxane问卷,PG组中有1例患者没有回复.EG组和PG组之间的基线QoL评分没有差异.在治疗期间,除了第11个疗程外,在第2-13个化疗疗程后,PG组紫杉烷亚量表评分显著高于EG组(均P<0.05).神经病变特异性分析显示PG组患者的神经病症状比EG组患者更早出现且更严重(P<0.001).结论在我们的QoL分析中,与PG方案相比,EG方案延迟并减少神经病变的发生.因此,艾日布林是MBC一线化疗药物紫杉醇的合理替代品.

作者 Korean Cancer Study Group ^[1] Ji-Yeon Kim ^[2] Seri Park ^[3] Seock-Ah Im ^[4] Sung-Bae im ^[5] Joohyuk Sohn ^[6] Keun Seok Lee ^[7] Yee Soo Chae ^[8] Ki Hyeong Lee ^[9] Jee Hyun Kim ^[1] Young-Hyuck Im ^[3] Tae-Yong Kim ^[3] Kyung-Hun Lee ^[4] Jin-Hee Ahn ^[5] Gun Min Kim ^[6] In Hae Park ^[7] Soo Jung Lee ^[8] Hye Sook Han ^[9] Se Hyun Kim ^[4] Kyung Hae Jung ^[10] Yeon Hee Park 学术成果认领

作者单位 Division of Hematology-Oncology,Department of Medicine,Samsung Medical Center,Sungkyunkwan University School of Medicine,81 Irwon-ro,Gangnam-gu,Seoul 06351,South Korea ^[1] Department of Health Sciencesand Technology,Samsung Advanced Institute for Health Sciences and Technology,Sungkyunkwan University,Seoul 06351,South Korea ^[2] Department of Internal Medicine,Seoul National University Hospital,Cancer Research Institute,College of Medicine,Seoul National University,Seoul 03080,South Korea ^[3] Department of Oncology,Asan Medical Center,University of Ulsan College of Medicine,Seoul 05505,South Korea ^[4] Division of Medical Oncology,Department of Internal Medicine,Yonsei University College of Medicine,Seoul 03722,South Korea ^[5] Center for Breast Cancer,National Cancer Center,Goyang 10408,South Korea ^[6] Department of Internal Medicine,Kyungpook National University Hospital,Daegu 41944,South Korea ^[7] Deparment of Internal Medicine,Chungbuk National University Hospital,Cheongju 28644,South Korea ^[8] Department of Internal Medicine,Seoul National University Bundang Hospital,Seoul National University College of Medicine,Seongnam 13620,South Korea ^[9] Division of Hematology-Oncology,Department of Medicine,Samsung Medical Center,Sungkyunkwan University School of Medicine,81 Irwon-ro,Gangnam-gu,Seoul 06351,South Korea;Department of Health Sciencesand Technology,Samsung Advanced Institute for Health Sciences and Technology,Sungkyunkwan University,Seoul 06351,South Korea ^[10]

关键词转移性乳腺癌艾日布林紫杉醇神经病生活质量癌症患者生命质量测评量表–紫杉烷问卷

主题词乳腺肿瘤(Breast Neoplasms)生活质量(Quality of Life)肿瘤(Neoplasms)肿瘤转移(Neoplasm Metastasis)性(Sex)

栏目名称 原创论著

发布时间 2020-01-07

基金项目

这项研究得到了韩国卫生和福利部 韩国卫生和福利部国家癌症控制研发计划

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准确一般字义偏差语意偏离译文作用小提交