Effects of immune cells and cytokines on the endometrial immune microenvironment in polycystic ovary syndrome

二维码有效期 120s

摘要Polycystic ovary syndrome(PCOS)is a common endocrine and metabolic disorder in women of reproductive age,and its pathogenesis is still unclear.More and more studies have shown that PCOS patients were often accom-panied by obesity,insulin resistance and chronic,low-grade inflammation,which were closely related to the endometrial dysfunction.Besides,obesity and insulin resistance also exacerbate inflammatory responses.Therefore,this review provides a summary of the effects of immune cells and inflammatory cytokines on the immune microenvironment of PCOS endometrium,and the impacts of obesity and insulin resistance on endo-metrial inflammatory homeostasis and possible drug interventions.

作者 Zhenhong Ye ^[1] Jie Zhao ^[1] Rong Li ^[1] 学术成果认领

作者单位 Center for Reproductive Medicine,Department of Obstetrics and Gynecology,Peking University Third Hospital,Beijing,100191,China;National Clinical Research Center for Obstetrics and Gynecology,Beijing,100191,China;Key Laboratory of Assisted Reproduction,Ministry of Education,Beijing,100191,China;Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology,Beijing,100191,China;Research Units of Comprehensive Diagnosis and Treatment of Oocyte Maturation Arrest,Chinese Academy of Medical Sciences,Beijing,100191,China ^[1]

关键词 Polycystic ovary syndrome Endometrium Immunity Cytokines

DOI 10.1016/j.gocm.2022.10.001

发布时间 2023-08-03

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