摘要A system is described here that can noninvasively control the navigation of freely behaving rat via ultrasonic, epidermal and LED photic stimulators on the back. The system receives commands from a remote host computer to deliver specified electrical stimulations to the hearing, pain and visual senses of the rat respectively. The results demonstrate that the three stimuli work in groups for the rat navigation. We can control the rat to proceed and make right and left turns with great efficiency. This experiment verified that the rat was able to reach a setting destination in the way of cable with the help of a person through the appropriate coordination of the three stimulators. The telemetry video camera mounted on the head of the rat also achieved distant image acquisition and helped to adjust its navigation path over a distance of 300 m. In a word, the non-invasive motion control navigation system is a good, stable and reliable bio-robot.