摘要Accurate detection of driver fatigue is essential for improving road safety.This study investigates the effectiveness of using multimodal physiological signals for fatigue detection while incorporating uncertainty quantification to enhance the reliability of predictions.Physiological signals,including Electrocardiogram(ECG),Galvanic Skin Response(GSR),and Electroencephalogram(EEG),were transformed into image representations and analyzed using pretrained deep neu-ral networks.The extracted features were classified through a feedforward neural network,and prediction reliability was assessed using uncertainty quantification techniques such as Monte Carlo Dropout(MCD),model ensembles,and combined approaches.Evaluation metrics included standard measures(sensitivity,specificity,precision,and accuracy)along with uncertainty-aware metrics such as uncertainty sensitivity and uncertainty precision.Across all evaluations,ECG-based models consistently demonstrated strong performance.The findings indicate that combining multimodal physi-ological signals,Transfer Learning(TL),and uncertainty quantification can significantly improve both the accuracy and trustworthiness of fatigue detection systems.This approach supports the development of more reliable driver assistance technologies aimed at preventing fatigue-related accidents.