摘要Wheat(Triticum aestivum)is a staple food for about 40％of the world's population.As the global population has grown and living standards improved,high yield and improved nutritional quality have become the main targets for wheat breeding.However,wheat production has been compromised by global warming through the more frequent occurrence of extreme temperature events,which have increased water scarcity,aggra-vated soil salinization,caused plants to be more vulnerable to diseases,and directly reduced plant fertility and suppressed yield.One promising option to address these challenges is the genetic improvement of wheat for enhanced resistance to environmental stress.Several decades of progress in genomics and genetic engineering has tremendously advanced our understanding of the molecular and genetic mecha-nisms underlying abiotic and biotic stress responses in wheat.These advances have heralded what might be considered a"golden age"of functional genomics for the genetic improvement of wheat.Here,we sum-marize the current knowledge on the molecular and genetic basis of wheat resistance to abiotic and biotic stresses,including the QTLs/genes involved,their functional and regulatory mechanisms,and strategies for genetic modification of wheat for improved stress resistance.In addition,we also provide perspectives on some key challenges that need to be addressed.