摘要N6-Methyladenosine(m6A)is one of the most abundant modifications of eukaryotic mRNA,but its compre-hensive biological functionality remains further exploration.In this study,we identified and characterized a new flowering-promoting gene,EARLY HEADING DATE6(EHD6),in rice.EHD6 encodes an RNA recognition motif(RRM)-containing RNA binding protein that is localized in the non-membranous cytoplasm ribonu-cleoprotein(RNP)granules and can bind both m6A-modified RNA and unmodified RNA indiscriminately.We found that EHD6 can physically interact with YTH07,a YTH(YT521-B homology)domain-containing m6A reader.We showed that their interaction enhances the binding of an m6A-modified RNA and triggers relocation of a portion of YTH07 from the cytoplasm into RNP granules through phase-separated conden-sation.Within these condensates,the mRNA of a rice flowering repressor,CONSTANS-like 4(OsCOL4),be-comes sequestered,leading to a reduction in its protein abundance and thus accelerated flowering through the Early heading date 1 pathway.Taken together,these results not only shed new light on the molecular mechanism of efficient m6A recognition by the collaboration between an RNA binding protein and YTH fam-ily m6A reader,but also uncover the potential for m6A-mediated translation regulation through phase-separated ribonucleoprotein condensation in rice.