摘要Nitrogen(N)and phosphorus(P)are indispensable macronutrients for crop growth and productivity;how-ever,their excessive application in agriculture has caused severe environmental degradation.Enhancing crop N-use efficiency(NUE)and P-use efficiency(PUE)is a critical strategy to reconcile high productivity with sustainability.In this review,we systematically synthesize recent advances in the genetic basis of NUE and PUE in crops,focusing on key traits and their associated signaling networks.We summarize the iden-tification of N/P-efficiency genes and explore how natural variations in these genes correlate with soil nutrient availability,revealing adaptive patterns from crop domestication.Given the distinct biogeochem-ical behaviors of N and P,we propose tailored strategies that leverage nutrient-specific traits to optimize environment-resource coordination and yield-quality balance.Finally,we discuss strategies for devel-oping future crop cultivars with enhanced NUE or PUE to advance sustainable agriculture.