Inhibition of Metalloproteinase Activity by Chinese Formulations Used to Treat Inflammatory Diseases

二维码有效期 120s

摘要Matrix metalloproteinases (MMPs) are known to be involved in a number of pathological processes including cancer, atherosclerosis, arthritis and neurodegenerative disease among others. The drive to develop MMP inhibitors as therapeutics has been put forward for years by pharmaceutical companies as well as academicians. In an attempt to screen for MMP inhibitors from Traditional Chinese Medicines (TCMs), a number of Chinese formulations used to treat inflammatory diseases such as nephritis and hepatitis have been studied. Strong inhibitory effects of three Chinese formulations toward the activity of MMP-16 have been discovered. These results suggest that these anti-inflammatory medicines contain some unknown MMP inhibitory compound(s) and provide reasonable molecular mechanisms for their therapeutic effects.

作者单位 Key Laboratory of Molecular Enzymology and Engineering, the Ministry of Education, Jilin University, Changchun 130021, P. R. China;School of Pharmacy, Jilin University, Changchun 130021, P. R. China ^[1] Key Laboratory of Molecular Enzymology and Engineering, the Ministry of Education, Jilin University, Changchun 130021, P. R. China;College of Life Science, Jilin University, Changchun 130021, P. R. China ^[2] The China-Japan Union Hospital, Jilin University, Changchun 130021, P. R. China ^[3] Key Laboratory of Molecular Enzymology and Engineering, the Ministry of Education, Jilin University, Changchun 130021, P. R. China ^[4]

关键词 Matrix metalloproteinase ( MMP )Matrix metalloproteinase inhibitor ( MMPI )Traditional ChineseMedicine (TCM)Herbal formulation

分类号 R5

栏目名称

Articles

发布时间 2008-01-07

基金项目

the National Natural Science Foundation of China（30371656）； Jilin Distinguished Young Scholars Program Grant Award（6-21-10）

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