摘要BACKGROUND:?Primary? graft? dysfunction? (PGD)? causes?complications?in?liver?transplantation,?which?result?in?poor?prognosis.?Recipients?who?develop?PGD?usually?experience?a?longer?intensive?care?unit?and?hospital?stay?and?have?higher?mortality?and?graft?loss?rates?compared?with?those?without?graft?dysfunction.?However,?because?of?the?lack?of?universally?accepted?deifnition,?early?diagnosis?of?graft?dysfunction?is?dififcult.?Additionally,?numerous?factors?affect?the?allograft?function?after?transplantation,?making?the?prediction?of?PGD?more?dififcult.?The?present?review?was?to?analyze?the?literature?available?on?PGD?and?to?propose?a?deifnition. <br> DATA?SOURCE:?A?search?of?PubMed?(up?to?the?end?of?2012)?for?English-language?articles?relevant?to?PGD?was?performed?to?clarify?the?characteristics,?risk?factors,?and?possible?treatments?or?interventions?for?PGD. <br> RESULTS:?There?is?no?pathological?diagnostic?standard;?many?documented?deifnitions?of?PGD?are?different.?Many?factors,?such?as?donor?status,?procurement?and?transplant?process?and?recipient?illness?may?affect?the?function?of?graft,?and?ischemia-reperfusion?injury?is?considered?the?direct?cause.?Potential?managements?which?are?helpful?to?improve?graft?function?were?investigated.?Some?of?them?are?promising. <br> CONCLUSIONS:?Our?analyses?suggested?that?the?deifnition?of?PGD?should?include?one?or?more?of?the?following?variables:?(1)?bilirubin?≥10?mg/dL?on?postoperative?day?7;?(2)?international?normalized?ratio?≥1.6?on?postoperative?day?7;?and?(3)?alanine?aminotransferase?or?aspartate?aminotransferase?>2000?IU/L?within?7?postoperative?days.?Reducing?risk?factors?may?decrease?the? incidence? of? PGD.? A? majority? of? the? recipients? could?recover?from?PGD;?however,?when?the?graft?progresses?into?primary?non-function,?the?patients?need?to?be?treated?with?re-transplantation.