摘要BACKGROUND: Enhanced recovery after surgery (ERAS) has improved postoperative outcomes particularly in colorectal surgery. This study aimed to assess compliance with an ERAS protocol and evaluate its effect on postoperative outcomes in patients undergoing pancreaticoduodenectomy. <br> METHODS: Fifty patients who had received conventional peri-operative management from 2005 to 2009 (conventional group) were compared with 75 patients who had received perioperative care with an ERAS protocol (fast-track group) from 2010 to 2014. Mortality, complications, readmissions and length of hospital stay were evaluated and compared in the groups. <br> RESULTS: Compliance with each element of the ERAS pro-tocol ranged from 74.7% to 100%. Uneventful patients had a signiifcant higher adherence to the ERAS protocol (87.5% vs 40.7%;P<0.001). There were no signiifcant differences in de-mographics and perioperative characteristics between the two groups. Patients in the fast-track group had a shorter time to remove the nasogastric tube, start liquid diet and solid food, pass lfatus and stools, and remove drains. No difference was found in mortality, relaparotomy, readmission rates and over-all morbidity. However, delayed gastric emptying and length of hospital stay were signiifcantly reduced in the fast-track group. The independent effect of the ERAS protocol in reduc-ing delayed gastric emptying and length of hospital stay was conifrmed by multivariate analysis. <br> CONCLUSION: ERAS pathway was feasible and safe in im-proving gastric emptying, yielding an earlier postoperative recovery, and reducing the length of hospital stay.