摘要To the Editor:The Pringle maneuver (PM) was initially described more than a century ago to control bleeding associated with hepatic trauma and it remains the most common method to block hepatic inflow and minimize blood loss during hepatic resections [1] . The po- tential effects of ischemia-reperfusion injury (IRI), a consequence of the PM, on the function of the liver remnant remain contro- versial [2] . Pre-clinical data have suggested that IRI may potenti- ate the growth of metastatic colorectal cells [3] , raising concerns regarding long-term oncological outcomes associated with use of the PM. Several large clinical studies involving patients undergoing resections for colorectal liver metastases (CRLM) have shown no significant differences in survival or hepatic recurrence regardless of whether the PM is used [ 4 , 5 ]. However, there remain concerns whether the PM may influence long-term oncological outcomes.