摘要Background: Robotic pancreaticoduodenectomy (RPD) has been reported to be safe and feasible for pa- tients with pancreatic ductal adenocarcinoma (PDAC) of the pancreatic head. This study aimed to analyze the surgical outcomes and risk factors for poor long-term prognosis of these patients. Methods: Data from patients who underwent RPD for PDAC of pancreatic head were retrospectively ana- lyzed. Multivariate Cox regression analysis was used to seek the independent prognostic factors for overall survival (OS), and an online nomogram calculator was developed based on the independent prognostic factors. Results: Of the 273 patients who met the inclusion criteria, the median operative time was 280.0 minutes, the estimated blood loss was 100.0 mL, the median OS was 23.6 months, and the median recurrence-free survival (RFS) was 14.4 months. Multivariate analysis showed that preoperative carbohydrate antigen 19- 9 (CA19-9) [hazard ratio (HR) = 2.607, 95％ confidence interval (CI): 1.560-4.354, P < 0.001], lymph node metastasis (HR = 1.429, 95％ CI: 1.005-2.034, P = 0.047), tumor moderately (HR = 3.190, 95％ CI: 1.813- 5.614, P < 0.001) or poorly differentiated (HR = 5.114, 95％ CI: 2.839-9.212, P < 0.001), and Clavien-Dindo grade ≥Ⅲ (HR = 1.657, 95％ CI: 1.079-2.546, P = 0.021) were independent prognostic factors for OS. The concordance index (C-index) of the nomogram constructed based on the above four independent prognostic factors was 0.685 (95％ CI: 0.640-0.729), which was significantly higher than that of the AJCC staging (8th edition): 0.541 (95％ CI: 0.493-0.589) ( P < 0.001). Conclusions: This large-scale study indicated that RPD was feasible for PDAC of pancreatic head. Preop- erative CA19-9, lymph node metastasis, tumor poorly differentiated, and Clavien-Dindo grade ≥Ⅲ were independent prognostic factors for OS. The online nomogram calculator could predict the OS of these patients in a simple and convenient manner.