摘要Background:Gallstone disease(GSD),nonalcoholic fatty liver disease(NAFLD),metabolic dysfunction-associated fatty liver disease(MAFLD),and metabolic syndrome(MetS)are common medical disorders worldwide.This study aimed to ascertain how NAFLD,MAFLD,MetS,and other factors affect the devel-opment of GSD,and how the GSD-associated factors influence patient recovery after laparoscopic chole-cystectomy(LC).Methods:We included 200 patients who were diagnosed with GSD and underwent LC between January 2017 and February 2022.A total of 200 subjects without GSD and"non-calculous causes"during the same period were also included as controls.We compared the metabolic disorder differences between GSD patients and controls.Furthermore,we sub-grouped patients based on the comorbidities of preoper-ative NAFLD,MAFLD,and MetS,and compared the impacts of these comorbidities on short-term post-LC functional recovery of the patients.Results:The prevalence of NAFLD and MetS were higher in GSD patients(P＜0.05).Based on multi-variate logistic regression analysis,hyperglycemia[odds ratio(OR)=2.2,95％confidence interval(CI):1.4-3.4,P=0.001]and low high-density lipoprotein cholesterol(HDL-C)level(OR=1.8,95％Cl:1.1-3.1,P=0.048)were linked to GSD.NAFLD and MetS linked to liver enzymes after LC(P＜0.05).MetS also linked to the levels of inflammatory indicators after LC(P＜0.05).The obesity,hyperlipidemia,low HDL-C level,and hyperglycemia linked to liver enzymes after LC(P＜0.05).Hyperlipidemia,low HDL-C level,and hypertension linked to inflammation after LC(P＜0.05).Conclusions:The prevalence of GSD may be linked to NAFLD and MetS.Hyperglycemia and low HDL-C level were independent risk factors of GSD.