摘要Background:Endoscopic papillectomy(EP)is an effective method to remove an ampulla of Vater(AoV)adenoma with minimal invasiveness.We reviewed the clinical outcomes and prognosis of patients un-dergoing EP,including tumor recurrence and adverse events.Methods:A total of 196 patients who underwent EP from January 2004 to December 2017 were included.Clinical information was collected through electronic medical records,and risk factors to predict post-procedural bleeding were analyzed using a multivariate logistic regression model.Results:A total of 93.9％patients(184/196)underwent complete resection.During the follow-up period,14.7％patients(27/184)experienced tumor recurrence,and two of seven surgically resected tumors were malignant.A total of 45.4％patients(89/196)experienced adverse events related to EP.Delayed bleed-ing occurred in 16.3％of the patients(32/196),and they were all successfully treated with endoscopic hemostasis and conservative management.The most frequent site of delayed bleeding was the distal end of the papillary orifice,and 56.3％(18/32)patients of delayed bleeding were classified as having mild severity,the others had moderate severity.Familial adenomatous polyposis(FAP)[odds ratio(OR)=3.80,95％confidence interval(CI):1.01-14.29;P＜0.05]and male sex(OR=2.82,95％CI:1.04-7.63;P=0.04)showed statistical significance in predicting delayed post-EP bleeding.Conclusions:EP for AoV adenoma was a highly effective and safe procedure.The risk of post-EP delayed bleeding was increased in patients with FAP syndrome and male patients,and post-EP bleeding occurred most commonly in the distal part of the AoV.