Salivary Gland Branching Morphogenesis- Recent Progress and Future Opportunities

二维码有效期 120s

摘要Salivary glands provide saliva to maintain oral health, and a loss of salivary gland function substantially decreases quality-of-life. Understanding the biological mechanisms that generate salivary glands during embryonic development may identify novel ways to regenerate function or design artificial salivary glands. This review article summarizes current research on the process of branching morphogenesis of salivary glands, which creates gland structure during development. We highlight exciting new advances and opportunities in studies of cell-cell interactions,mechanical forces, growth factors, and gene expression patterns to improve our understanding of this important process.

作者单位 Laboratory of Cell and Developmental Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, USA ^[1]

关键词 salivary gland epithelium branching morphogenesis fibronectin E-cadherin growth factor

分类号 R78

DOI 10.4248/IJOS10042

发布时间 2010-10-29

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