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Indigenous microbiota protects development of medication-related osteonecrosis induced by periapical disease in mice

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摘要INTRODUCTIONAnti-resorptive treatment (ART) with agents such as bispho-sphonate (BPs) or denosumab (Dmab) is commonly practiced in patients with osteoporosis and bone metastatic diseases.1 In patients undergoing a long-term ART, a rare intraoral lesion called medication-related osteonecrosis of the jaw (MRONJ) may develop, which is clinically defined as exposed bone through intraoral and/or extraoral fistula that persists for more than 8 weeks without a history of radiation therapy.

作者 Wen Du ^[1] Mengyu Yang ^[2] Terresa Kim ^[2] Sol Kim ^[2] Drake W.Williams ^[2] Maryam Esmaeili ^[2] Christine Hong ^[3] Ki-Hyuk Shin ^[4] Mo K.Kang ^[4] No-Hee Park ^[5] Reuben H.Kim ^[6] 学术成果认领

作者单位 State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases&Department of Prosthodontics,West China Hospital of Stomatology,Sichuan University,Chengdu,China;The Shapiro Family Laboratory of Viral Oncology and Aging Research,Los Angeles,USA ^[1] The Shapiro Family Laboratory of Viral Oncology and Aging Research,Los Angeles,USA;Section of Restorative Dentistry,UCLA School of Dentistry,Los Angeles,USA ^[2] Department of Orofacial Sciences,UCSF School of Dentistry,San Francisco,USA ^[3] The Shapiro Family Laboratory of Viral Oncology and Aging Research,Los Angeles,USA;UCLA Jonsson Comprehensive Cancer Center,Los Angeles,USA ^[4] The Shapiro Family Laboratory of Viral Oncology and Aging Research,Los Angeles,USA;UCLA Jonsson Comprehensive Cancer Center,Los Angeles,USA;David Geffen School of Medicine at UCLA,Los Angeles,USA ^[5] The Shapiro Family Laboratory of Viral Oncology and Aging Research,Los Angeles,USA;Section of Restorative Dentistry,UCLA School of Dentistry,Los Angeles,USA;UCLA Jonsson Comprehensive Cancer Center,Los Angeles,USA ^[6]

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ORIGINAL ARTICLES

发布时间 2022-07-06（万方平台首次上网日期，不代表论文的发表时间）

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