换一批MSCs-derived apoptotic extracellular vesicles promote muscle regeneration by inducing Pannexin 1 channel-dependent creatine release by myoblasts
摘要INTRODUCTIONSkeletal muscles are one pivotal organ in human body, accounting for 35％–45％ of body weights, with indispensable roles in the motion system.1–2 Muscle injuries occur frequently in daily life and mild muscle trauma could be cured without resulting in a poor prognosis, however, severe muscle trauma always led to muscle degeneration and dysfunction3. During muscle regeneration process after trauma, the improper regeneration of myofibers often caused decreased functional capacity of muscle, resulting in muscle atrophy or necrosis, diminishing functional capacity, and compromising life quality in consequence.
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