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A biomimetic nanoplatform for customized photothermal therapy of HNSCC evaluated on patient-derived xenograft models

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摘要INTRODUCTIONPhotothermal therapy (PTT), a noninvasive therapy that does not suffer from restriction of chemo-resistance or radio-resistance, has demonstrated promising prospects for cancer treatment.1–2 In the case of superficial tumors such as head and neck squamous cell carcinoma (HNSCC), near-infrared (NIR) light responsive PTT is preferable due to effective photo penetration.3–5 Besides direct damage to cancer cells, PTT has also been shown to promote immunogenic cell death (ICD), a process that causes cancer cells to release tumor-associated antigens, which further trigger the anti-tumor immune response,6–7 generating the cytotoxic T lymphocytes (CTLs) to eliminate residual tumor cells and inhibit its metastasis.

作者 Qi Wu ^[1] Lan Chen ^[1] Xiaojuan Huang ^[1] Jiayi Lin ^[2] Jiamin Gao ^[1] Guizhu Yang ^[1] Yaping Wu ^[1] Chong Wang ^[1] Xindan Kang ^[1] Yanli Yao ^[1] Yujue Wang ^[1] Mengzhu Xue ^[1] Xin Luan ^[2] Xin Chen ^[3] Zhiyuan Zhang ^[1] Shuyang Sun ^[1] 学术成果认领