The Effect of Cyclic Stretching on Matrix Production, Mineralization and Differentiation of Osteoblasts

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摘要A four-point bending apparatus is used to investigate the effects of stretching on collagen synthesis, mineralization and differentiation of osteoblasts. Cells are stretched at 1500 με for 24 hours. The responses of osteoblasts to mechanical signal of physiological stretching are evaluated from three aspects: collagen production, extracellular inorganic calcium secretion and ALP activity. The results show that osteoblasts decrease the collagen synthesis, calcium secretion and ALP activity compared to the control cells (65.82%,73.51%,48.10% respectively), confirming that cyclic stretching at 1500 με inhabits the physiological activity of osteoblasts.

作者秦建 ^[1] TANG LILING ^[1] Wang Yuanliang ^[1] Gu Li ^[1] 学术成果认领

作者单位 Bioengineering College, Key Lab for Biomechanics & Tissue Engineering under the State Ministry of Education,Chongqing University, Chongqing 400044,P.R.China ^[1]

关键词 osteoblast mechanical stretching matrix synthesis differentiation mineralization

分类号 R318

DOI 10.3772/j.issn.1006-6748.2003.03.007

发布时间 2003-11-14

基金项目

国家自然科学基金

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