摘要目的 系统评价清开灵注射液治疗脑出血急性期的疗效及安全性.方法 全面检索清开灵治疗脑出血的随机对照试验,结局指标包括总有效率、病死率、神经功能缺损评分、血肿容积测量及不良反应等.采用RevMan5软件进行Meta分析.结果 共检索到12个试验包括1 197例病人.(1)清开灵组的总有效率优于对照组[RR 1.19,95%CI(1.1 2,1.26);P<0.00 001];(2)清开灵组的病死率低于对照组[RR 0.50,95%CI(0.36,0.69);P<0.0 001];(3)清开灵组的神经功能缺损评分改善情况优于对照组[z=26.28,P<0.00 001];(4)对各个试验进行单独分析的结果显示清开灵组在改善血肿容积方面优于对照组.结论 现有的有限证据表明,清开灵治疗脑出血急性期患者有效,可降低病死率,改善神经功能缺损评分,改善血肿容积.

abstractsObjective To evaluate eficaey and safety of qingkailing injecfion for acute cerebral hemorrhage.Methods Randomized controlled trails(RCTs)of qingkailing injec-tion for acute cerebral hemorrhage were identified,eligible studies were included,the outcome we compared included:total efficacy rate,case fatality rate,improvement on neu-rological function loss rate,reduction on haematoma volume and Security.RevMan 5 software and Meta-analysis were used to analyse the data.Results 12 RCTs and 1 197 patients were included,with all trails of low methodological quality.Qingkalling injection VS routine- treatment control,Meta-analysis indicated that(1) the total effective rate of Qingkailing injection is superior to control[RR 1.19,95%CI(1.12,1.26);P<O.O0001];(2) case fatal-ity rate of Qingkailing injection is less than control[RR 0.50,95%CI(0.36,0.69);P<0.0001];(3) Qingkailing injection's effect on improving neurological function loss rate is superior to control[Z=26.28,P<O.O0 001];(4) trails were analysed separately and the results showed that Qingkailing injection is superior to control on reducing the haematoma volume.Conclusion This systematic review showed that qingkailing injecfion is elective for acute cerebral hemorrhage.However the evidence is not strong due to the general low methodological quality.To determinately evaluate eficacy and safety of qingkailing injec-tion for acute cerebral hemorrhage,more rationally designed and strictly executed RCTs with large samples are necessary.