摘要目的 探讨偏头痛患者发作期、间歇期外周血 NO、ET-1含量的变化.方法 采用分光光度计及放射免疫法分别测定45例偏头痛患者发作期、41例偏头痛患者间歇期血清NO、ET-1含量,同时与健康查体者进行对照.结果 偏头痛患者发作期血清NO、ET-1含量均明显高于健康对照组;间歇期患者血清NO含量明显下降,接近于健康对照组,而ET-1含量仍维持较高水平,与发作期患者比较无明显差异,而与健康对照组比较则差异明显.结论 偏头痛患者发作期外周血NO、ET-1含量明显增高;间歇期患者NO含量接近正常水平,而ET-1含量仍维持在较高水平;NO及ET-1含量增高及平衡紊乱是偏头痛发生的重要影响因素.

abstractsObjective To explore the changes in peripheral levels of nitric oxide (NO) and endothelin-1 (ET-1) in migraine patients during attack and interictal period. Methods Serum levels of NO and ET-1 were detected by spectrophotometry and radioimmunoassay in 45 patients with migraine attack and 41 patients in the interictal period. The results were compared with those from healthy subjects.Results Levels of NO and ET-1 were significantly higher in the patients with attack than in the healthy subjects. NO levels decreased significantly in the interictal period, being close to those from the healthy subjects, while ET-1 levels remained at a higher level, which had no significant difference as compared with those in the interictal period, but significantly different from the normal group. Conclusions Peripheral levels of NO and ET-1 levels obviously elevate in migraine attack; NO levels return to nearly normal interictal periods while ET-1 levels remained at a higher level. Increased levels of NO and ET-1 and disbalance between them are an important cause of migraine attack.