摘要目的 观察硫酸氢氯吡格雷联合低分子肝素钙治疗进展性脑梗死的疗效及副作用.方法 117例患者随机分为治疗组62例和对照组55例,治疗组第一天给予硫酸氢氯吡格雷300mg,首剂口服,第二天起75 mg qd × 13d,低分子肝素钙4000Iu ih q12 h×7 d;对照组予阿司匹林肠溶片;两组同时酌情予降压、调控血糖、血脂、脱水及改善脑细胞代谢药物.结果 治疗组显效率(80.6%)及总有效率(91.9%)与对照组比较差异有显著性(P＜0.01).结论 两种药物联合治疗进展性脑梗死有协同作用且安全有效.

abstractsObjective To explore the curative effects of clopidogrel bisulfate combined with low molecular weight heparin in the treatment of acute progressive cerebral infarction. Methods 117 patients with progressive cerebral infarction were randomly divided into two groups, There were 62 patients in the treatment group and 55 patients in the control group. In the treatment group, clopidogrel bisulfate 300mg was apphed initial dose, followed by 75mg qd×13d and the low molecular weight Heparin 4000IU, twice a day,subcutaneous injection,for 7d; the control group were treated with oral enteric-coated aspirin 100mg, once a day. All of them were controlled with blood glucose, blood pressure, blood fat, dehydration and improved brain cells metabolism etc. Results The curative effects were compared between two groups, the treatment group was much better than that in the control group(P＜ 0.01) Conclusion Clopidogrel bisulfate combined with low molecular weight heparin in the treatment of acute progressive cerebral infarction is effective and safe.