摘要目的 总结糖尿病(diabetes mellitus,DM)患者神经损害特点及危险因素.方法 将我院360例DM患者按有无合并糖尿病神经病变(diabetic peripheral neuropathy,DPN)分为研究组和对照组各180例,进行空腹血糖水平测定,并对每位患者体重指数、血脂水平、血压水平、DM病程进行统计；对疑似有相关病变的DPN患者进行胫神经的感觉及运动神经传导速度测定.结果 DPN组与对照组相比年龄更大、病程更长,并且收缩压(SBP)、糖化血红蛋白(HbA1c)高于对照组(P＜0.05),单因素Logistic回归分析显示患者年龄(OR=1.059,95％CI=1.039-1.078,P＜0.01)、病程(OR=1.082,95％CI=1.051-1.164,P＜0.01)、收缩压(OR=1.040,95％CI=0.020-1.058,P＜0.01)和血糖指标(OR=0.142,95％CI=0.039-0.389,P＜0.01)是DN的危险因素.结论 血糖越高、病程越长、神经损伤越重、高血压是DPN发生的危险因素.

abstractsObjective To investigate the clinical risk factors of diabetic newly diagnosed with peripheral neuropathy.Methods 160 diabetics newly diagnosed were randomly selected and divided into diabetic peripheral neuropathy (DPN) group and non diabetic peripheral neuropathy(non-DPN) group.Clinical characteristics,including blood pressure,fasting and postprandial blood glucose,HbA1c,lipid profiles,uric acid,insulin were statistically summarized.Data was evaluated using analysis of SPSS 18.0.Results 360 diabetics were screened.The DPN group showed older age,higher systolic blood pressure and higher HbA1c P ＜ 0.05.Logistic analysis screened that HbA1c was the independent risk factor for DPN(P ＜ 0.05).Conclusion DPN has higher incidence in DM newly diagnosed.Hyperglycemia is important risk factor.