摘要目的 探讨血清超敏C反应蛋白(hsCRP)和血浆D-二聚体(D-D)在慢性阻塞性肺疾病急性加重期(AECOPD)中的临床意义.方法 对72例COPD急性加重期患者在入院治疗前和经治疗病情稳定后进行血清hsCRP和血浆D-D水平测定,同时选择48例健康体检者作为对照组,对上述检测结果进行比较和分析.结果 AECOPD患者治疗前血清hsCRP和血浆D-D分别为(33.65±10.72) mg/L和(708±141)μg/L较稳定期的(11.08±6.5) mg/L和(332±64)μg/L明显增高,差异均有显著性(P＜0.05);两组分别与对照组hsCRP(0.78±0.41) mg/L和血浆D-D(177±55) μg/L对比差异均有显著性(P＜0.05),其中比治疗前比较差异有极显著性(P＜0.01).结论 hsCRP和D-D是反映COPD急性加重期感染和疗效的敏感指标,动态监测对于评价病情具有一定的临床意义.

abstractsObjective To study the significance of serum high sensitivity C-reactive protein(hsCRP)in patients with acute exacerbation of chronic obstructive pulmonary disease( AECOPD).Methods 72 patients with AECOPD were determined with hs-CRP and D-dime before and after treatment.48 healthy persons were set to normal control group,and the results were compared and analyzed between the two groups.Results The serum hs-CRP and D-dime levels in AECOPD were higher than those in the stable COPD group,there were statistically significant differences ( P＜ 0.05 ); compared with control group,there were significant differences between the two groups ( P＜ 0.05 ),the differences of AECOPD group were obviously particularly significant ( P＜O.O1 ).Conclu8ions hs-CRP and D-dime are sensitive indexes to infection and curative effect judgment,dynamic monitoring for the assessment has some clinical significance.