摘要目的 探讨立体定向放射治疗(SRT)联合化疗治疗放疗后局部复发非小细胞肺癌的疗效.方法 将本院96例局部复发非小细胞肺癌患者随机分为两组,对照组48例给予常规化疗,试验组48例在对照组基础加用SRT;比较两组临床疗效及生存预后的差异.结果 试验组患者完全缓解率、总缓解率分别为37.5％、58.3％,均高于对照组的8.3％、22.9％,差异均有统计学意义(均P＜0.05);试验组患者1年、2年病死率分别为16.7％、25.0％,均低于对照组的39.6％、47.9％,差异均有统计学意义(均P＜0.05).结论 SRT联合化疗治疗放疗后局部复发非小细胞肺癌效果佳,其临床缓解率高,病死率低,值得临床选择.

abstractsObjective To explore the clinical effect of stereotactic radiation therapy (SRT) combining chemotherapy in the treatment of locally recurrent non-small cell lung cancer (NSCLC) after radiotheroapy.Methods 96 patients with locally recurrent NSCLC were randomly divided into a control group and a test group,48 cases for each group.The control group were treated by conventional chemotherapy;in addition,the test group were treated by SRT.The clinical effects and prognosis of the two groups were compared.Results The complete remission rate and total remission rate were higher in the test group than in the control group (37.5％ vs.8.3％ and 58.3％ vs.22.9％,both P ＜ 0.05).The death rates 1 and 2 years after the treatment were lower in the test group than control group (16.7％ vs.39.6％ and 25.0％ vs.47.9％,both P ＜ 0.05).Conclusions SRT combining chemotherapy for patients with locally recurrent NSCLC is effective and can improve the remission rate and reduce the death rate,so it is a good choice in clinical practice.