摘要目的 探讨2HRZSU6HRL方案治疗复治涂阳肺结核病患者的应用价值.方法 选取2017年4月至2018年12月本院复治涂阳肺结核病患者120例,按随机对照原则分为两组,各60例.观察组接受含左氧氟沙星的化疗(2HRZSU6HRL)方案治疗,对照组接受3HRZE/6HRE常规化疗方案.比较两组治疗效果.结果 观察组病灶吸收率、空洞闭合率、痰菌转阴率分别为95.0％、85.0％、86.7％,均高于对照组76.7％、51.7％、68.317毛,差异均有统计学意义(均P ＜ 0.05);观察组不良反应发生率 18.3％与对照组23.3％比较,差异无统计学意义(P＞ 0.05).结论 2HRZSL/6HRL方案治疗复治涂阳肺结核病获得明显效果,不良反应少,值得推广应用.

abstractsObective To explore the value of 2HRZSL/6HRL in the treatment of patients with recurrent smear positive pulmonary tuberculosis.Methods 120 patients with smear positive pulmonary tuberculosis treated at our hospital from April,2017 to December,2018 were selected,and divided into an observation group(n=60)and a control group according to the random control principle.The observation group received the chemotherapy regimen containing levofloxacin(2HRZSL/6HRL),and the control group the routine chemotherapy regimen of 3HRZE/6HRE.The therapeutic effects of the two groups were compared.Results The focal absorption rate,the cavity closure rate,the sputum negative conversion rate were higher in the observation group than in the control group(95.0％vs.76.7％,85.0％vs.51.7％,and 86.7％vs.68.3％; all P ＜ 0.05).The incidence of adverse reactions was 18.3％in the observation group,and 23.3％in the control group(P ＞ 0.05).Conclusion 2HRZSL/6HRL regimen for patients with recurrent smear positive pulmonary tuberculosis is effective and has few adverse reactions,so it is worthy of promotion.