摘要目的:探讨GnRha降调和非降调下激素替代-冻融胚胎移植周期中不同内源性促黄体生成素（LH）增高水平对妊娠结局的影响。方法:回顾性分析2015年1月至2018年10月在本院行GnRha降调和非降调下激素替代-冻融胚胎移植（HRT-FET）且年龄≤35周岁以及基础LH水平<10 IU/L的非子宫内膜异位症患者2 313个周期的临床资料。根据有无GnRha降调分为降调下HRT-FET组（225个）和无降调HRT-FET组（2 088个），再将无降调HRT-FET患者根据冻融胚胎移植中最高一次的LH水平分为3组：A组（LH<10 IU/L）、B组（LH 10～19.99 IU/L）和C组（LH≥20 IU/L）。比较无降调HRT-FET患者不同LH水平组间妊娠结局的差异和进一步比较无降调LH升高患者（≥20 IU/L ）和降调下LH降低（LH<10 IU/L）患者妊娠率等结局的差异。结果:A、B、C 3组患者的取卵年龄、移植胚胎数、妊娠率和种植率均无统计学差异（均 P>0.05），GnRha降调组较非降调组患者的妊娠率和种植率明显降低（均 P<0.05）。 结论:非子宫内膜异位症患者HRT-FET中出现LH增高对妊娠结局可能无不良影响，GnRha降调并不改善妊娠率。

abstractsObjective:To investigate the effect of different elevated luteinizing hormone (LH) levels on pregnancy outcomes of women in the cycle of hormone replace treatment and frozen-thawed embryo transfer (HRT-FET) with or without GnRha.Methods:The clinical data of 2 313 cycles of non-endometriosis women with the age ≤35 years old and basic LH <10 IU/L who underwent HRT-FET with or without GnRha in our hospital from January 2015 to October 2018 was retrospectively analyzed. According the usage of GnRha or not, they were divided into GnRha HRT-FET group (225 cycles) and HRT-FET group (2 088 cycles). According to the highest level of endogenous LH in HRT-FET group, the cycles were divided into three groups: group A (<10 IU/L), group B (10-19.99 IU/L), and group C (≥20 IU/L). The pregnancy outcomes among different groups were compared.Results:There were no statistically significant differences in age of egg retrieval, number of embryo transfer, clinical pregnancy rate, and planting rate among group A, B, C (all P>0.05). The clinical pregnancy rate and planting rate in GnRha HRT-FET group were significantly lower than those in HRT-FET group (all P<0.05). Conclusions:Maybe there were no adverse effects of increased level of endogenous LH on pregnancy outcomes in HRT-FET cycles for non-endometriosis patients. The usage of GnRha does not increase the pregnancy rate.